Are Soybean Sterols Safe for Long Term Use? What You Need to Know Are Soybean Sterols Safe for Long Term Use? What You Need to KnowGlycine soja soybean sterols, naturally occurring compounds derived from soybeans, have gained attention for their cholesterol-lowering properties and role in supporting heart health. Research spanning decades suggests these plant-based sterols are generally safe for long-term consumption when used within recommended guidelines....